nfP2X7
BIOSCEPTRE’S UNIQUE TARGET – nfP2X7
P2X7 is an ion channel found on the surface of normal cells. In cancer, it becomes non-functional (nf) and that is important for cancer cells to survive. At the same time it changes shape providing a target for therapeutic intervention.
nfP2X7 is expressed on approximately 44% of tested cancers.
- ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival
SM Gilbert, CJ Oliphant, S. Hassan, AL Peille, P. Bronsert, S. Falzoni, F. Di Virgilio, S. McNulty, R. Lara